Healthy

Collagen: Sources and Health Benefits

Collagen: Sources and Health Benefits

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In this article, you will learn about:

  • What is collagen;
  • Where and how it is produced;
  • Collagen performs many important functions in the body. It is a protein that is the main component of connective tissues such as skin, tendons, cartilage, and bone. Due to its strength and elasticity, collagen provides structure and support to various organs and systems.

    In the skin, collagen is responsible for its elasticity and youthfulness, helping to retain moisture and prevent wrinkles. In bones, it contributes to their strength, and in tendons and ligaments, it contributes to flexibility and resistance to stress. Collagen also plays a role in tissue healing, helping to repair damaged areas.

    As we age, collagen levels in the body decline, which can lead to various problems, such as loss of skin elasticity, osteoporosis, and joint pain. Therefore, maintaining adequate levels through diet, supplements, or other methods becomes an important aspect of health care.

  • A collagen deficiency can be determined by a number of signs. Firstly, it's worth paying attention to the condition of the skin: if it becomes less elastic, wrinkles appear, and it becomes generally dull, this may indicate a collagen deficiency. Secondly, joint pain and a crunching sound when moving also indicate a possible deficiency of this protein.

    Furthermore, brittle nails and hair that loses strength and shine may indicate insufficient collagen levels. Slow wound healing and an increased susceptibility to injury are also important signals. If you notice these symptoms, you may want to consider increasing your collagen intake through diet or supplements.

  • Collagen can be found in a variety of foods. The main source of this protein is animal products, especially broths made from animal bones, skin, and cartilage. These broths are rich in collagen, which is released during prolonged simmering.

    Collagen is also present in meat, especially in parts containing connective tissue, such as beef, pork, and chicken. Fish and seafood, especially those with skin, are also good sources of this protein.

    Furthermore, plant foods contain substances that promote collagen production. These include foods rich in vitamin C, such as citrus fruits, berries, peppers, and green leafy vegetables. Also important are foods high in antioxidants, such as nuts and seeds, which help protect collagen from breakdown.

    Don't forget about collagen supplements, which are available in powder and capsule form. These supplements can provide an additional source of collagen for those looking to maintain healthy skin, joints, and other tissues.

  • Comparing collagen from supplements and that found in foods raises many questions. Collagen from supplements is often hydrolyzed, which makes it easier for the body to absorb. These supplements can be a convenient way to ensure you're getting enough collagen, especially for those who don't get enough from their diet.

    On the other hand, collagen found in natural foods, such as bone broth, fish, and meat, may have its own benefits. When you eat collagen-rich foods, the body receives not only the protein itself but also other beneficial substances that promote its synthesis and absorption.

    Ultimately, the choice between collagen from supplements and food depends on individual preferences and needs. Some people may prefer supplements for convenience, while others will strive to get collagen from natural sources.

  • There are various factors that contribute to the destruction of collagen in the body. First and foremost, this is age-related changes. Over time, collagen production levels decrease, leading to a decrease in its amount in tissues. Sun exposure also has a negative impact; ultraviolet radiation can damage collagen fibers, accelerating the aging process of the skin.

    Smoking is another factor that destroys collagen. Nicotine and other substances in cigarettes contribute to poor circulation, which makes it difficult for essential nutrients to reach the skin. Poor nutrition and a lack of vitamins and minerals, especially vitamin C, also affect collagen synthesis.

    Stress and lack of sleep can negatively affect the condition of the skin and reduce collagen production. Additionally, certain diseases and inflammatory processes in the body can also have a destructive effect on collagen fibers. Overall, many factors can contribute to collagen deterioration, which affects the health of the skin and other tissues.

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What is collagen

Collagen is the most abundant protein in the human body and makes up about 30% of the total volume of protein compounds. The etymology of the word "collagen" goes back to the Greek term "kolla", which translates as "glue". This name quite accurately reflects the role of collagen fibers, which provide support, connect various tissues and protect them.

Places and processes of collagen formation: where and how it is formed

The structure of the collagen molecule resembles a strong rope formed from three interwoven strands. Each of these strands consists of amino acids, which are the basic "building blocks" of protein, such as glycine, proline and lysine.

Collagen is formed in the body through two main stages. First, its synthesis occurs, which begins in cells known as fibroblasts, which are found in connective tissues. These cells produce collagen precursors called procollagen. Then, in the second stage, procollagen undergoes a modification process that includes its conversion into mature collagen. This process occurs in the extracellular space, where collagen molecules assemble into strong fibers, providing tissue with strength and elasticity.

  • The first stage is an intracellular process. Formation of the collagen "precursor" occurs thanks to fibroblasts—cells with starfish-like processes. Inside the fibroblasts, the amino acids glycine, proline, and lysine are combined into a long chain, resulting in the formation of procollagen. Vitamin C plays a key role in this process, facilitating enzymes in their work of modifying and packaging amino acids into a single structure.
  • The second stage, called the extracellular stage, completes the process of collagen formation in the intercellular space. Initially, each individual strand is twisted into a spiral shape, resembling a spring. Then, three such spirals join together, forming a strong triple structure, similar to a rope. The spirals then combine into threads called fibrils, which then form thick fibers that give tissue the necessary rigidity. Copper ions, which participate in the “cross-linking” of the chains between themselves, play an important role in this process.
Infographics: Maya Malgina for Skillbox Media

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The Role of Collagen in the Functioning of the Human Body

The collagen family includes at least 29 varieties. However, only four of them are most widespread.

  • Type I is the most stable, providing support for bones, skin, tendons, and internal organs. It makes up about 90% of all collagen present in the human body.
  • Type II has flexible and shock-absorbing properties and is found in the cartilage of the intervertebral discs, as well as in joints. At the same time, its volume can decrease as a result of intense physical activity.
  • Type III is a thin type of collagen that helps maintain the elasticity of both muscle tissue and blood vessels.
  • Type IV does not create fibers, but instead forms layers that perform the function of separating different tissues.

Signs of collagen deficiency: how to recognize them?

The body constantly undergoes a process of collagen replacement. Fibroblasts are responsible for the synthesis of new fibers, while enzymes break down "obsolete" structures. However, both the breakdown and synthesis of collagen occur slowly, which results in different rates of renewal of its types: some are renewed in just a few days, while others require a whole year.

When the process of collagen breakdown exceeds the rate of its formation, the following changes can occur: [8]:

  • the skin loses its luster, and wrinkles appear on the facial surface.
  • muscle mass decreases and loses its strength.
  • ligaments and tendons lose their elasticity, which makes them susceptible to easy stretching.
  • When cartilage in the joints is destroyed, a specific crunching sound can occur, as well as a feeling of discomfort or pain.
  • Blood circulation becomes less effective, which is why the healing process of any damage is delayed.

9 Foods That Help Naturally Increase Collagen Levels in the Body

You Can Is it possible to get collagen through food? Absolutely, since this protein is an important part of our diet. However, the absorption of collagen from food presents certain difficulties. Any protein entering the body is first broken down into amino acids, which are then used to form its own protein molecules, including collagen. Therefore, our diet also requires foods containing cofactors—vitamins and microelements that facilitate the process of "assembling" collagen fibers.

Thus, proteins and cofactors are necessary for collagen synthesis in the body. Which foods can provide these components?

Hard parts of the carcass, such as shank, are rich in collagen. This animal protein provides amino acids in a proportion that promotes the formation of the collagen triple helix. However, excessive consumption of red meat, especially processed meats, can have negative health effects.

Researchers from Oxford University found that daily consumption of 70 grams of raw red meat and processed meat increases the risk of cardiovascular disease by 15% and the risk of diabetes by 30%.

70 grams of meat is a small portion that can serve as the basis for a full meal. This amount corresponds to approximately 100-150 grams of raw meat, depending on the type of meat and cooking method. For comparison, this amount of meat can be used to prepare one or two cutlets, a small steak, or as an addition to a salad.

  • Two wide strips of bacon.
  • 1.5 sausages;
  • half a burger;
  • ⅓ of a steak;
  • Five tablespoons of cooked ground meat.

Read also:

Meat: harm and benefit

Bone broth is capable of collecting a significant amount of collagen. The key is long cooking over low heat, which should last at least 4 hours, and sometimes up to 24 hours. In addition, vinegar is added to the process, which facilitates the separation of collagen and its conversion to gelatin. In this form, the absorption of this substance by the body is much easier.

Chicken meat is a source of complete protein, which includes all nine essential amino acids, including lysine. Amino acids that the body cannot synthesize on its own from other amino acids are called essential.

In addition, chicken breast is a source of a significant amount of protein, while containing a minimal amount of fat. Unlike red meat, such restrictions do not apply to chicken.

Seafood contains the so-called "marine collagen". Research shows that this type of collagen is absorbed by the body more efficiently than collagen obtained from other sources. It's important to note that its concentration in fish is lower than in meat. However, eating fish also provides valuable omega-3 fatty acids. Although omega-3s are not involved in the process of collagen synthesis, they promote healing and tissue regeneration.

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Fish has many beneficial properties and is an important component of the diet. It's rich in protein, vitamins, and healthy fats like omega-3, which promote cardiovascular health, improve brain function, and help prevent various diseases.

However, not everyone is recommended to eat fish. People with allergies to seafood or certain types of fish may experience negative effects from consuming it. Additionally, it's important to consider that some types of fish may contain high levels of mercury and other contaminants, making them less safe for certain groups of people, such as pregnant women and children. Therefore, before including fish in your diet, you should consult with your doctor to ensure it's right for you.

Collagen is a protein found exclusively in animal sources and is not found in plant sources. However, legumes such as beans are rich in lysine, which plays an important role in the production of collagen fibers in the body.

Australian researchers have found that daily consumption of 50 grams of legumes, which is about a quarter of a cup, helps increase lifespan.

Eggs do not contain collagen, but they made our list because they can provide tissues with another important amino acid - proline.

Should you limit yourself to just the protein, or can you include whole eggs in your diet? If you have high cholesterol, you may want to avoid the yolks. However, a study published in the Journal of the American Heart Association, which involved nearly half a million people in China, shows that eating up to one egg a day can reduce the risk of cardiovascular disease and stroke. The researchers also noted that the participants did not follow a Western diet or consume fatty foods, which can raise cholesterol levels.

Oranges, grapefruits, lemons, and limes are citrus fruits that are a source of vitamin C. As mentioned earlier, this vitamin is key to the synthesis of procollagen, which serves as a precursor to collagen in our bodies.

These foods contain zinc and copper, which help improve collagen production in the body. They can be used in Greek yogurt or added to citrus smoothies, which will make a snack even more nutritious.

Read also:

Cashews, like many other nuts, have both positive and negative health properties. On the one hand, they are a valuable source of nutrients. They contain many vitamins, minerals, and healthy fats that help strengthen the immune system and maintain normal body function. For example, cashews contain magnesium, which is important for cardiovascular health, as well as B vitamins, which promote metabolism.

However, despite all their benefits, cashews are not without their drawbacks. They are quite high in calories, and excessive consumption can lead to excess weight gain. Furthermore, some people may experience allergic reactions to these nuts, making their consumption dangerous for certain groups.

Thus, cashews can be a healthy addition to the diet, but it is important to eat in moderation and take into account individual characteristics.

Gelatin is a large collagen molecule extracted from the bones, joints, and various types of connective tissue in animals. It is most commonly produced from pigs and cows, but other sources include fish and marine organisms, chicken, and seaweed.

Gelatin has a clear structure and no distinct flavor, making it a popular choice for making drug capsules and as a culinary additive. This type of collagen contributes to the gelatinous texture, jelly, and stability of products such as jellies and cakes.

Gelatin, which is extracted from collagen, is a protein compound composed entirely of amino acids. The composition of these amino acids in gelatin can vary depending on its source, but in most cases it includes proline and glycine, which play a key role in the synthesis of the body's own collagen.

Collagen Comparison: Natural Sources or Supplements?

Advertising campaigns for dietary supplements aim to portray collagen as a key element in promoting a healthy lifestyle. It is even recommended to add collagen tablets or powdered forms to coffee. The main arguments in favor of this are:

  • Our bodies do not get younger with age, and the process of collagen production begins to slow down after reaching the age of 20, decreasing by 1-1.5% every year. In this context, additional measures to maintain healthy skin will be very useful.
  • The muscle tissue of meat and fish contains significantly lower collagen fibers than, for example, skin, cartilage, bones, or tendons. It is from these parts of animals that dietary supplements are produced.

However, the collagen contained in dietary supplements is not more effective or beneficial compared to a complete diet that includes sufficient protein. Recognizing this, researchers have made cautious claims about the benefits of collagen supplements.

  • They may be "quite effective" in improving skin quality, relieving joint discomfort, and maintaining bone health;
  • Using 10 milligrams daily is likely safe, but is not recommended for longer than five months.

There is currently no information on the safety of collagen supplements taken for more than five months [24]. It is also necessary to take into account that in Russia the market of food supplements is not strictly controlled, therefore, without a diagnosed deficiency and consultation with a specialist, it is not recommended to use any dietary supplements, even those available in pharmacy chains.

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Dietary supplements (DS) are products that contain various components, such as vitamins, minerals, herbs or other Substances intended to improve health and overall well-being. These supplements can be used to complement the diet or to support a specific therapeutic process.

The safety of dietary supplements remains a pressing and controversial issue. Although many are available over-the-counter and widely advertised, it is important to understand that not all supplements undergo the rigorous clinical trials that are required for conventional medications. Therefore, it is recommended to consult with a doctor or qualified healthcare professional before using them. This will help avoid possible side effects or interactions with other medications.

Three key aspects that negatively affect collagen levels in the body

How can you slow down collagen loss? This issue, although important, is rarely discussed, and some even prefer to ignore it.

Experts from the Cleveland Clinic identify three key factors that can significantly accelerate the destruction of collagen fibers, and their influence is much more powerful than age.

  • Excessive sugar consumption in the diet can lead to glucose oxidation in the body. This process leads to the formation of advanced glycation end products, which damage proteins, which, in turn, makes collagen more brittle.
  • Ultraviolet radiation has a significant impact on the skin. Excessive amounts of sunlight lead to a decrease in collagen synthesis and also accelerate the destruction of existing collagen.
  • Smoking has a negative impact on fibroblasts, which are responsible for the synthesis of collagen types I and III, reducing their activity. In addition, nicotine causes blood vessels in the skin to constrict, which hinders the flow of oxygen and essential nutrients such as amino acids, vitamins, and minerals.

Read also:

Effective Smoking Cessation: A Step-by-Step Guide

1. Identify Your Reasons. Start by understanding why you want to quit smoking. Write down your motivations – it could be a desire to improve your health, save money, or protect loved ones from secondhand smoke.

2. Set a date. Choose a specific day to quit smoking for good. Prepare for this moment by eliminating all cigarettes and smoking accessories in advance.

3. Prepare for the process. Explore different methods and strategies that can help you along the way. Consider using nicotine replacements, such as patches or gum, to ease withdrawal symptoms.

4. Find support. Reach out to friends, family, or professional counselors for help. The support of those around you can have a significant impact on your success.

5. Change habits. Analyze your habits and triggers that provoke the desire to smoke. Try to avoid situations that can provoke a relapse and find alternative ways to relax.

6. Manage stress. Find healthy stress relief techniques, such as exercise, meditation, or hobbies, to help distract you from smoking.

7. Celebrate your achievements. Reward yourself for each day without smoking. Keep a journal where you can record your achievements and progress, which will help maintain motivation.

8. Be prepared for difficulties. Understand that the process of quitting smoking can be difficult and will take time. If you relapse, do not despair and continue moving towards your goal.

9. Constantly remind yourself of your reasons. Regularly return to your records of motivation and achievements to maintain determination and not forget why you started this journey.

10. Enjoy your freedom. Once you quit smoking for good, enjoy the benefits, such as improved health, cost savings, and a higher quality of life.

What can we conclude from this?

Collagen can be considered the basis of our body's structure, playing a key role in ensuring skin elasticity, tendon strength, and bone flexibility. However, when it comes to external sources of collagen, we encounter many misconceptions. One such misconception is that collagen contained in supplements directly penetrates the skin or joints. In fact, this is impossible, as our body is very wary of foreign proteins that may pose a threat. Therefore, before use, these proteins are first broken down into amino acids, and only then used for collagen synthesis.

Certainly, taking collagen supplements can be useful for those who, for various reasons, have difficulty getting enough protein from food. For example, vegetarians or people with digestive problems may more easily absorb collagen in the form of peptides, which are almost completely digested.

However, no collagen supplement can guarantee a "rejuvenating" effect.

First of all, it should be noted that a balanced diet is the best way to provide the body with sufficient collagen through food. Collagen is produced in our body naturally, provided that we get enough protein, as well as essential vitamins and minerals. In addition, by maintaining a healthy lifestyle, avoiding smoking, excess consumption of simple carbohydrates, and excessive exposure to sunlight, we are able to preserve existing collagen in the body longer.

Sources

1. Collagen. School of Public Health named after Harvard T. H. Chan School of Medicine.

Shenoy, M., Abdul, N. S., Qamar, Z., Bahri, B. M. A., Ghalaini, K. Z. K. A., and Kakti, A. Collagen structure, synthesis, and applications: a systematic review. Cureus. 2022. DOI: 10.7759/cureus.24856.

Potekhina, Y. Collagen structure and functions. Russian Osteopathic Journal. 2016. 1–2: 87–99. DOI: 10.32885/2220-0975-2016-1-2-87-99.

Añazco C., Ojeda P. G., y Guerrero-Wyss M. Los frijoles comunes como fuente de aminoácidos y cofactores para la biosíntesis de colágeno. Nutrientes. 2023. 15(21). 4561. DOI: 10.3390/nu15214561.

Shih E. Clinical and pharmacological aspects of the use of hydrolyzed collagen type II for the prevention and treatment of osteoarthritis. Pharmacology and Pharmacotherapy. 2021. 4. 10–19. DOI: 10.46393/2713-2129_2021_4_10_18.

Karsdal M. Biochemistry of collagens, laminins, and elastin: structure, functions, and biomarkers. Elsevier, 2023.

Shavlovskaya O. A., Gromova O. A., and Torshin I. Y. investigate the use of undenatured collagen type II in the treatment of musculoskeletal pain syndromes. In the journal "S. S. Korsakov Neurology and Psychiatry" for 2022, volume 122, issue 11, page 40. DOI: 10.17116/jnevro202212211140.

Expand list

Wang H. A review of the effects of collagen treatment in clinical trials. Polymers. 2021. 13(22) 3868. DOI: 10.3390/polym13223868.

Meat consumption increases the likelihood of developing cardiovascular disease, diabetes and pneumonia, reports The Guardian.

Alcock R. D., Shaw G. C., and Burke L. M. argue that bone broth is unlikely to provide stable levels of collagen precursors compared with collagen supplements used in scientific studies. This article was published in the International Journal of Sport Nutrition and Exercise Metabolism in 2018, issue 29, pages 265–272. DOI: 10.1123/ijsnem.2018-0139.

11. Proteins in Nutrition. National Library of Medicine.

Geahchan S., Baharlouei P., and Rahman A. in their article “Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Antiaging, and Bone Regeneration” examine the potential of marine collagen as an innovative material. The publication appeared in Marine Drugs in 2022, including issue 20, number 1, on page 61. DOI: 10.3390/md20010061.

Pu S., Huang Y., Pu C., Kang Y., Hoang K. D., Chen K., and Chen C. Conducting a systematic review and meta-analysis of the effects of oral collagen on skin aging. Nutrients. 2023. 15(9). 2080. DOI: 10.3390/nu15092080.

Alipoor E., Jazayeri S., Dahmardehei M., Salehi S., Yaseri M., Emami M. R., Rezayat S. M., and Hosseinzadeh-Attar M. J. conducted a study to evaluate the effects of a collagen-enriched drink with or without added omega-3 fatty acids on wound healing, metabolic biomarkers, and adipokines in patients with severe burns. The results of the study were published in the journal Clinical Nutrition in 2023, including issue 42, number 3, pages 298–308. DOI: 10.1016/j.clnu.2022.12.014.

Hughes, J., Pearson, E., and Grafenauer, S. conducted a thorough examination of legumes in the context of global food-based dietary guidelines and their consumption. This study was published in the journal Nutrients in 2022, Volume 14, Issue 15, Article Number 3080. DOI: 10.3390/nu14153080.

Attia, Y. A., Al-Harthi, M. A., Korish, M. A., and Shiboob, M. H. conducted a study on the protein and amino acid content of four brands of eggs sold in retail chains. The study was published in Animals in 2020, Volume 10, Issue 3, Article 406. DOI: 10.3390/ani10030406.

Qin C., Lv J., Guo Y., Bian Z., Si J., Yang L., Chen Y., Zhou Y., Zhang H., Liu J., Chen J., Chen Z., Yu C., and Li L. conducted a study that examined the association between egg consumption and cardiovascular disease in a cohort of 500,000 Chinese adults. The results were published in Heart in 2018, Issue 104, Issue 21, pages 1756–1763. DOI: 10.1136/heartjnl-2017-312651.

DePhillipo N. N., Aman Z. S., Kennedy M. I., Begley J., Moatshe G., and LaPrade R. F. conducted a systematic review examining the effectiveness of vitamin C supplementation on collagen synthesis and oxidative stress after musculoskeletal injuries. The results were published in the Orthopaedic Journal of Sports Medicine in 2018, issue 6, number 10. DOI: 10.1177/2325967118804544.

19. Raw nuts, in particular cashews. U.S. Department of Agriculture.

Samatra M. Y., Noor N. Q. I. M., Razali U. H. M., Bakar J., and Shaarani S. M. investigated bovine-based gelatin, covering its extraction methods, physicochemical and functional characteristics, applications, and future development prospects. This work was published in Comprehensive Reviews in Food Science and Food Safety in 2022, Volume 21, Issue 4, Pages 3153–3176. DOI: 10.1111/1541-4337.12967.

21. Gelatin. National Library of Medicine.

Naomi R., Bahari H., Ridzuan P. M., and Ortman F. conducted an expert review focusing on natural biomaterials used for skin wound healing, comparing gelatin and collagen. The results of their study were published in the journal Polymers in 2021, including Volume 13, Issue 14, Number 2319. DOI: 10.3390/polym13142319.

Reilly, D. M., and Lozano, H. Exploring skin collagen across life stages: Its implications for skin health and beauty. Plastic and Aesthetic Science. 2021. Volume 8, Issue 2. DOI: 10.20517/2347-9264.2020.153.

24. Collagen peptides. National Library of Medicine.

25. Questions and Answers about Dietary Supplements. U.S. Food and Drug Administration.

26. Dietary Guidelines for Americans 2020–2025. Make the most of every serving, based on the ninth edition of the Dietary Guidelines. DietaryGuidelines.gov.

Collagen. Cleveland Clinic.

Knuutinen A., Kokkonen N., Risteli J., Vahakangas K., Kallioinen M., Salo T., Sorsa T., and Oikarinen A. investigated the effects of smoking on collagen synthesis and extracellular matrix turnover in human skin. This work was published in the British Journal of Dermatology in 2002, volume 146, issue 4, pages 588–594. DOI: 10.1046/j.1365-2133.2002.04694.x.